- Abstract:
-
The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cells. Cish was rapidly induced in response to IL-15, and deletion of Cish rendered NK cells hypersensitive to IL-15, as evidenced by enhanced proliferation, survival, IFN-γ producti...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 29.0MB)
-
(pdf, 155.9KB)
-
(pdf, 1.3MB)
-
- Publisher copy:
- 10.1038/ni.3470
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Immunology Journal website
- Volume:
- 17
- Pages:
- 816–824
- Publication date:
- 2016-05-23
- DOI:
- EISSN:
-
1529-2916
- ISSN:
-
1529-2908
- URN:
-
uuid:a2dd7142-2d7e-45a3-8275-c833f797780d
- Source identifiers:
-
625356
- Local pid:
- pubs:625356
- Language:
- English
- Keywords:
- Copyright holder:
- Delconte et al.
- Copyright date:
- 2016
- Notes:
- Author(s) retain copyright. This is the accepted manuscript version of the article. The final version is available online from Nature Publishing Group at: [10.1038/ni.3470]
Journal article
CIS is a potent checkpoint in NK cell-mediated tumor immunity.
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National Health and Medical Research Council of Australia
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