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The evolutionary landscape of colorectal tumorigenesis

Abstract:

The evolutionary events that cause colorectal adenomas (benign) to progress to carcinomas (malignant) remain largely undetermined. Using multi-region genome and exome sequencing of 24 benign and malignant colorectal tumours, we investigate the evolutionary fitness landscape occupied by these neoplasms. Unlike carcinomas, advanced adenomas frequently harbour sub-clonal driver mutations—considered to be functionally important in the carcinogenic process—that have not swept to fixation, and have...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41559-018-0642-z

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
Mustonen, V More by this author
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ORCID:
0000-0002-0165-292X
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Ecology and Evolution Journal website
Volume:
2
Pages:
1661–1672
Publication date:
2018-08-31
Acceptance date:
2018-07-12
DOI:
ISSN:
2397-334X
Pubs id:
pubs:914597
URN:
uri:a2ce9a44-8d14-4d13-9f21-a82192e1e16a
UUID:
uuid:a2ce9a44-8d14-4d13-9f21-a82192e1e16a
Local pid:
pubs:914597
Language:
English
Keywords:

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