- The first highly enantioselective, direct organocatalytic conjugate addition of unmodified aldehydes to alkylidinemalonates is presented. The reaction gives access to β-formyl-substituted malonates and highly functionalized lactones with up to 14:1 dr and generally 94 to >99% ee. © 2008 Wiley-VCH Verlag GmbH and Co. KGaA.
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Organocatalytic highly enantioselective conjugate addition of aldehydes to alkylidine malonates
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