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Augmented reduced-intensity regimen does not improve postallogeneic transplant outcomes in acute myeloid leukemia

Abstract:

PURPOSE: Reduced-intensity conditioning (RIC) regimens have extended the curative potential of allogeneic stem-cell transplantation to older adults with high-risk acute myeloid leukemia (AML) and myelodysplasia (MDS) but are associated with a high risk of disease relapse. Strategies to reduce recurrence are urgently required. Registry data have demonstrated improved outcomes using a sequential transplant regimen, fludarabine/amsacrine/cytarabine-busulphan (FLAMSA-Bu), but ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
American Society of Clinical Oncology Publisher's website
Journal:
Journal of Clinical Oncology Journal website
Article number:
JCO2002308
Publication date:
2020-12-29
Acceptance date:
2020-12-01
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
Pmid:
33373276
Pubs id:
1151733
Local pid:
pubs:1151733
Language:
English
Keywords:
Format:
Print-Electronic

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