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Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast.

Abstract:

Individual patient data were available for all four of the randomized trials that began before 1995, and that compared adjuvant radiotherapy vs no radiotherapy following breast-conserving surgery for ductal carcinoma in situ (DCIS). A total of 3729 women were eligible for analysis. Radiotherapy reduced the absolute 10-year risk of any ipsilateral breast event (ie, either recurrent DCIS or invasive cancer) by 15.2% (SE 1.6%, 12.9% vs 28.1% 2 P <.00001), and it was effective regardless of th...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
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Journal:
Journal of the National Cancer Institute. Monographs
Volume:
2010
Issue:
41
Pages:
162-177
Publication date:
2010
DOI:
EISSN:
1745-6614
ISSN:
1052-6773
URN:
uuid:a26ef862-793c-4137-915f-60ecb2ec226f
Source identifiers:
245929
Local pid:
pubs:245929

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