Functional replacement of oxygen by other oxidants in articular cartilage.
OBJECTIVE: Articular cartilage chondrocytes consume remarkably little O(2) in comparison with most other animal cells; glycolysis forms the principal source of ATP in this cartilage. Although not lethal for many days, imposition of anoxia immediately lowers intracellular ATP, inhibits rates of glycolysis, and prevents articular chondrocytes from producing extracellular matrix macromolecules. This study was undertaken to investigate the role of O(2) in articular chondrocyte metabolism. METHOD...Expand abstract
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