Challenging the Binary Classification of Endometrioid Endometrial Adenocarcinoma: The Evaluation of Grade 2 as an Independent Entity Based on Prognostic Characteristics and Recurrence Patterns

Journal article

Background: Although grade is a well-recognised prognostic factor for endometrioid endometrial cancer (EEC), in more studies grade 1 (G1) and grade 2 (G2) EEC are combined and compared together with grade 3 (G3) tumours. The aim of our study is to separately investigate the outcomes, prognostic factors and recurrence patterns of G2 EEC and whether the differentiation between G1 and G2 EEC is clinically useful. Methods: we retrospectively reviewed 523 patients with EEC treated with primary surgery over a decade (March 2010-January 2020) at Oxford University Hospitals NHS Trust, focusing on those with G2 disease. Results: Patients with G2 EEC had worse 5-year cancer-specific survival (93.3% vs. 98.5%, p p = 0.04) and cancer-specific survival (93.3% vs. 78.5%, p Conclusions: our results suggest that the grading system should continue to differentiate G1 EEC and G2 EEC for better prognosis interpretation.

Authors: Zouridis, A; Kashif, A; Darwish, A; Pappa, C; Ferrari, F

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: MDPI
• Journal: Cancers
• Volume: 17
• Issue: 1
• Pages: 127
• Publication date: 2025-01-03
• Acceptance date: 2024-12-30
• DOI: 10.3390/cancers17010127
• EISSN: 2072-6694
• ISSN: 2072-6694
• Pmid: 39796755
• Language: English
• Keywords: Low Grade; Endometrioid Endometrial Cancer; Moderately Differentiated; G2; Grade 2