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Selective deactivation of serum IgG: a general strategy for the enhancement of monoclonal antibody receptor interactions.

Abstract:

Serum IgG is a potent inhibitor of monoclonal antibody (mAb) binding to the cell-surface Fcγ receptors (FcγRs), which mediate cytotoxic and phagocytic effector functions. Here, we show that this competition can be eliminated, selectively, by the introduction to serum of (i) an enzyme that displaces Fc from FcγRs and (ii) a modification present in the therapeutic mAb that renders it resistant to that enzyme. Specifically, we show that (i) EndoS (endoglycosidase S) cleaves only complex-type gly...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2012.04.002

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Journal:
Journal of molecular biology
Volume:
420
Issue:
1-2
Pages:
1-7
Publication date:
2012-06-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:a22625fb-22b5-4b69-ac76-da48cc8da10a
Source identifiers:
322687
Local pid:
pubs:322687

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