Experiments with the site frequency spectrum.

Journal article

Evaluating the likelihood function of parameters in highly-structured population genetic models from extant deoxyribonucleic acid (DNA) sequences is computationally prohibitive. In such cases, one may approximately infer the parameters from summary statistics of the data such as the site-frequency-spectrum (SFS) or its linear combinations. Such methods are known as approximate likelihood or Bayesian computations. Using a controlled lumped Markov chain and computational commutative algebraic methods, we compute the exact likelihood of the SFS and many classical linear combinations of it at a non-recombining locus that is neutrally evolving under the infinitely-many-sites mutation model. Using a partially ordered graph of coalescent experiments around the SFS, we provide a decision-theoretic framework for approximate sufficiency. We also extend a family of classical hypothesis tests of standard neutrality at a non-recombining locus based on the SFS to a more powerful version that conditions on the topological information provided by the SFS.

Authors: Sainudiin, R; Thornton, K; Harlow, J; Booth, J; Stillman, M

• Publication status: Published
• Journal: Bulletin of mathematical biology
• Volume: 73
• Issue: 4
• Pages: 829-872
• Publication date: 2011-04-01
• DOI: 10.1007/s11538-010-9605-5
• EISSN: 1522-9602
• ISSN: 0092-8240
• Language: English
• Keywords: Population Growth; Markov Chains; Pedigree; Base Sequence; Population Density; Stochastic Processes; Algorithms; Likelihood Functions; Models, Genetic; Probability; Heterozygote; Computer Simulation; Bayes Theorem; Genetics, Population; Sequence Alignment; Mutation; Monte Carlo Method