Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

Journal article

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Authors: Barton, A; Thomson, W; Ke, X; Eyre, S; Hinks, A

• Publication status: Published
• Journal: Nature genetics
• Volume: 40
• Issue: 10
• Pages: 1156-1159
• Publication date: 2008-10-01
• DOI: 10.1038/ng.218
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Case-Control Studies; BIRAC Consortium; Polymorphism, Single Nucleotide; Humans; Wellcome Trust Case Control Consortium; Chromosomes, Human, Pair 10; Arthritis, Rheumatoid; Chromosome Mapping; Genetic Linkage; YEAR Consortium; Chromosomes, Human, Pair 22; Genetic Predisposition to Disease; Chromosomes, Human, Pair 12