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Differential cytokine levels in adults induced by a Novel candidate TB boost vaccine, MVA85A-according to previous BCG vaccination status

Abstract:

MVA85A is a candidate boost vaccine for TB. A previously reported study showed no differences in response to MVA85A in 10 BCG vaccinated (BCG+) and 11 BCG naive (BCG-) adult Gambians. Here we evaluated the effect of pre-existing plasma cytokines in both groups before and after MVA85A vaccination on the vaccine-induced immune response. Pre-vaccination levels of IL-8 were higher in BCG+ subjects, whilst MCP-1 levels were lower compared to BCG-. Following MVA85A vaccination, concentrations of IL...

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Publisher copy:
10.4172/2157-7560.1000158

Authors


Owiafe, PK More by this author
Ibanga, HB More by this author
Brookes, RH More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
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Journal:
Journal of Vaccines and Vaccination
Volume:
3
Issue:
7
Publication date:
2012-11-05
DOI:
EISSN:
2157-7560
URN:
uuid:a19789b5-e02b-4530-bebf-538ae60963b2
Source identifiers:
411853
Local pid:
pubs:411853
Language:
English
Keywords:

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