Journal article
Differential cytokine levels in adults induced by a Novel candidate TB boost vaccine, MVA85A-according to previous BCG vaccination status
- Abstract:
- MVA85A is a candidate boost vaccine for TB. A previously reported study showed no differences in response to MVA85A in 10 BCG vaccinated (BCG+) and 11 BCG naive (BCG-) adult Gambians. Here we evaluated the effect of pre-existing plasma cytokines in both groups before and after MVA85A vaccination on the vaccine-induced immune response. Pre-vaccination levels of IL-8 were higher in BCG+ subjects, whilst MCP-1 levels were lower compared to BCG-. Following MVA85A vaccination, concentrations of IL-8, IL-18, IL-12(p70) and MCP-1 were differentially induced between BCG+ and BCG- groups. The implications of these findings depend on their role in TB pathogenesis.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.4MB, Terms of use)
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- Publisher copy:
- 10.4172/2157-7560.1000158
Authors
- Journal:
- Journal of Vaccines and Vaccination More from this journal
- Volume:
- 3
- Issue:
- 7
- Article number:
- 1000158
- Publication date:
- 2012-11-30
- Acceptance date:
- 2012-11-28
- DOI:
- EISSN:
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2157-7560
- Language:
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English
- Keywords:
- Pubs id:
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pubs:411853
- UUID:
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uuid:a19789b5-e02b-4530-bebf-538ae60963b2
- Local pid:
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pubs:411853
- Source identifiers:
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411853
- Deposit date:
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2013-11-17
Terms of use
- Copyright holder:
- Owiafe et al.
- Copyright date:
- 2012
- Rights statement:
- © 2012 Owiafe PK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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