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Autoantibodies to islet amyloid polypeptide in diabetes.

Abstract:

Islet amyloid polypeptide (IAPP) is the constituent peptide of amyloid in pancreatic islets of Type 2 diabetic patients and in insulinomas. Amyloid formation in Type 2 diabetes is associated with islet cell destruction which may promote formation of autoantibodies to IAPP. An ELISA method has been developed to detect IAPP autoantibodies and used to assay serum from 80 non-diabetic subjects, 49 Type 1 and 228 Type 2 diabetic patients, and 10 patients with insulinomas. Microtitre plates coated ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM, Biomedical Research Centre
Role:
Author
Journal:
Diabetic medicine : a journal of the British Diabetic Association
Volume:
8
Issue:
7
Pages:
668-673
Publication date:
1991-01-01
DOI:
EISSN:
1464-5491
ISSN:
0742-3071
URN:
uuid:a1914620-7875-45a3-9cdf-692c623e538d
Source identifiers:
22210
Local pid:
pubs:22210

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