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The extent of axonal loss in the long tracts in hereditary spastic paraplegia.

Abstract:

Hereditary spastic paraplegia (HSP) comprises a group of inherited neurodegenerative disorders with the shared characteristics of progressive weakness and spasticity predominantly affecting the lower limbs. Limited pathological accounts have described a 'dying back' axonal degeneration in this disease. However, the distribution and extent of axonal loss has not been elucidated in a quantitative way. We have studied post-mortem material from six HSP patients and 32 controls in detail. The popu...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, WTC Human Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Neuropathology and applied neurobiology
Volume:
30
Issue:
6
Pages:
576-584
Publication date:
2004-12-05
DOI:
EISSN:
1365-2990
ISSN:
0305-1846
URN:
uuid:a18cc5de-2415-46c2-99eb-a213ed71a788
Source identifiers:
32908
Local pid:
pubs:32908

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