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Journal article

Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.

Abstract:

The mechanisms by which nucleotides stimulate the activity of the ATP-regulated K(+)-channel (KATP-channel) were investigated using inside-out patches from mouse pancreatic beta-cells. ATP produces a concentration-dependent inhibition of channel activity with a Ki of 18 microns. The inhibitory action of ATP was counteracted by ADP (0.1 mM) and GDP (0.2 mM) but not GTP (1 mM). Stimulation of channel activity was also observed when ADP, GDP and GTP were applied in the absence of ATP. The abilit...

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Publication status:
Published

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Publisher copy:
10.1098/rspb.1991.0022

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
Proceedings. Biological sciences / The Royal Society
Volume:
243
Issue:
1307
Pages:
139-144
Publication date:
1991-02-01
DOI:
EISSN:
1471-2954
ISSN:
0962-8452
Source identifiers:
22057
Language:
English
Keywords:
Pubs id:
pubs:22057
UUID:
uuid:a180e328-d20d-494f-a2ca-a26d2f04d7a7
Local pid:
pubs:22057
Deposit date:
2012-12-19

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