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Journal article

Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.

Abstract:

The mechanisms by which nucleotides stimulate the activity of the ATP-regulated K(+)-channel (KATP-channel) were investigated using inside-out patches from mouse pancreatic beta-cells. ATP produces a concentration-dependent inhibition of channel activity with a Ki of 18 microns. The inhibitory action of ATP was counteracted by ADP (0.1 mM) and GDP (0.2 mM) but not GTP (1 mM). Stimulation of channel activity was also observed when ADP, GDP and GTP were applied in the absence of ATP. The abilit...

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Publication status:
Published

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Publisher copy:
10.1098/rspb.1991.0022

Authors


Bokvist, K More by this author
Ammälä, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Berggren, PO More by this author
Larsson, O More by this author
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Journal:
Proceedings. Biological sciences / The Royal Society
Volume:
243
Issue:
1307
Pages:
139-144
Publication date:
1991-02-05
DOI:
EISSN:
1471-2954
ISSN:
0962-8452
URN:
uuid:a180e328-d20d-494f-a2ca-a26d2f04d7a7
Source identifiers:
22057
Local pid:
pubs:22057

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