We report the isolation and structural determination of fourteen iminosugars, containing five pyrrolizidines and five indolizidines, from Castanospermum australe. The structure of a new alkaloid was elucidated by spectroscopic methods as 6,8-diepi-castanospermine (13). Our side-by-side comparison between bicyclic and corresponding monocyclic iminosugars revealed that inhibition potency and spectrum against each enzyme are clearly changed by their core structures. Castanospermine (10) and 1-de...Expand abstract
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articletitle: Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors
copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.
2014 Elsevier Ltd. All rights reserved.