Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors.
We report the isolation and structural determination of fourteen iminosugars, containing five pyrrolizidines and five indolizidines, from Castanospermum australe. The structure of a new alkaloid was elucidated by spectroscopic methods as 6,8-diepi-castanospermine (13). Our side-by-side comparison between bicyclic and corresponding monocyclic iminosugars revealed that inhibition potency and spectrum against each enzyme are clearly changed by their core structures. Castanospermine (10) and 1-de...Expand abstract
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articletitle: Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors
copyright: Copyright © 2014 Elsevier Ltd. All rights reserved.
2014 Elsevier Ltd. All rights reserved.