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Isolation and SAR studies of bicyclic iminosugars from Castanospermum australe as glycosidase inhibitors.

Abstract:

We report the isolation and structural determination of fourteen iminosugars, containing five pyrrolizidines and five indolizidines, from Castanospermum australe. The structure of a new alkaloid was elucidated by spectroscopic methods as 6,8-diepi-castanospermine (13). Our side-by-side comparison between bicyclic and corresponding monocyclic iminosugars revealed that inhibition potency and spectrum against each enzyme are clearly changed by their core structures. Castanospermine (10) and 1-de...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.phytochem.2014.12.011

Authors


Hirokami, Y More by this author
Miyawaki, S More by this author
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Leverhulme Research Fellowship More from this funder
National Science Foundation More from this funder
Skaggs–Oxford Scholarship More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Phytochemistry Journal website
Volume:
111
Pages:
124-131
Publication date:
2015-03-05
DOI:
EISSN:
1873-3700
ISSN:
0031-9422
URN:
uuid:a177e71a-4073-4c9b-b38c-c372b04aefe1
Source identifiers:
504733
Local pid:
pubs:504733

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