Use of causal diagrams to inform the analysis and interpretation of observational studies: An example from the Study of Heart and Renal Protection (SHARP)

Journal article

Observational studies often seek to estimate the causal relevance of an “exposure” to an “outcome” of interest. However, many possible biases can arise when estimating such relationships, in particular bias due to confounding. To control for confounding properly, careful consideration of the nature of the assumed relationships between the exposure, the outcome and other characteristics is required. Causal diagrams provide a simple graphical means of displaying such relationships, describing the assumptions made and allowing for the identification of a set of characteristics that should be taken into account (ie, “adjusted for”) in any analysis. Furthermore, causal diagrams can be used to identify other possible sources of bias (such as selection bias) which, if understood from the outset, can inform the planning of appropriate analyses. In this article, we review the basic theory of causal diagrams and describe some of the methods available to identify which characteristics need to be taken into account when estimating the net effect of an exposure on an outcome. In doing so, we review the concept of “collider bias” and show how it is inappropriate to adjust for characteristics that may be influenced, directly or indirectly, by both the exposure and outcome of interest. A motivating example is taken from the Study of Heart and Renal Protection, in which the relevance of smoking to progression to end-stage renal disease is considered.

Authors: Staplin, N; Herrington, W; Judge, P; Reith, C; Haynes, R

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Society of Nephrology
• Journal: Clinical Journal of the American Society of Nephrology
• Publication date: 2016-08-01
• Acceptance date: 2016-07-13
• DOI: 10.2215/CJN.02430316
• EISSN: 1555-905X
• ISSN: 1555-9041, 1555-905X