Journal article
MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution
- Abstract:
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Disruption of the class I human leukocyte antigen (HLA) molecules has important implications for immune evasion and tumor evolution. We developed major histocompatibility complex loss of heterozygosity (LOH), allele-specific mutation and measurement of expression and repression (MHC Hammer). We identified extensive variability in HLA allelic expression and pervasive HLA alternative splicing in normal lung and breast tissue. In lung TRACERx and lung and breast TCGA cohorts, 61% of lung adenoca...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1038/s41588-024-01883-8
Authors
Bibliographic Details
- Publisher:
- Nature Research
- Journal:
- Nature Genetics More from this journal
- Volume:
- 56
- Issue:
- 10
- Pages:
- 2121-2131
- Publication date:
- 2024-10-02
- Acceptance date:
- 2024-07-25
- DOI:
- EISSN:
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1546-1718
- ISSN:
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1061-4036
Item Description
- Language:
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English
- Source identifiers:
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2381361
- Deposit date:
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2024-10-30
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