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Journal article

E-selectin is a viable route of infection for polymer-coated adenovirus retargeting in TNF-α-activated human umbilical vein endothelial cells.

Abstract:

BACKGROUND: E-selectin is an attractive endothelial cell surface marker in inflammation and cancer. PURPOSE: We sought to investigate retargeting of adenovirus via E-selectin as a viable pathway of infection in tumor necrosis factor-α (TNF-α)-activated human umbilical vein endothelial cells (HUVECs). METHODS: E1, E3-deleted Ad5 expressing cytomegalovirus immediate-early (CMV IE) promoter-driven luciferase (Adluc) was coated with an amino-reactive multivalent hydrophilic polymer based on poly ...

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Publication status:
Published

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Journal:
Journal of drug targeting
Volume:
19
Issue:
8
Pages:
690-700
Publication date:
2011-09-05
DOI:
EISSN:
1029-2330
ISSN:
1061-186X
URN:
uuid:a14ecb07-c86b-49ff-8e12-410cbc8480ff
Source identifiers:
179405
Local pid:
pubs:179405

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