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Bromodomains as therapeutic targets.

Abstract:

Acetylation of lysine residues is a post-translational modification with broad relevance to cellular signalling and disease biology. Enzymes that 'write' (histone acetyltransferases, HATs) and 'erase' (histone deacetylases, HDACs) acetylation sites are an area of extensive research in current drug development, but very few potent inhibitors that modulate the 'reading process' mediated by acetyl lysines have been described. The principal readers of ɛ-N-acetyl lysine (K(ac)) marks are bromodoma...

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Publication status:
Published

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Publisher copy:
10.1017/s1462399411001992

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Journal:
Expert reviews in molecular medicine
Volume:
13
Pages:
e29
Publication date:
2011
DOI:
EISSN:
1462-3994
ISSN:
1462-3994
URN:
uuid:a14aae17-2efd-4778-bd86-1af49b0ea1d7
Source identifiers:
177446
Local pid:
pubs:177446

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