Journal article
Molecular monitoring of the Leu-164 mutation of dihydrofolate reductase in a highly sulfadoxine/pyrimethamine-resistant area in Africa.
- Abstract:
-
The selection of point mutation at codon 164 (from isoleucine to leucine) of the dihydrofolate reductase (DHFR) enzyme in Plasmodium falciparum is associated with high sulfadoxine /pyrimethamine (SP) resistance. Using the yeast expression system that allows the detection of dhfr allele present at low level, the presence of this mutation had previously been reported between 1998-1999 in Muheza, Tanzania, an area of high SP resistance. Eighty five P. falciparum isolates, obtained from the same ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- BioMed Central Publisher's website
- Journal:
- Malaria Journal Journal website
- Volume:
- 2
- Issue:
- 1
- Article number:
- 46
- Publication date:
- 2003-12-01
- DOI:
- EISSN:
-
1475-2875
- ISSN:
-
1475-2875
Item Description
- Language:
- English
- UUID:
-
uuid:a137a56d-d54d-48e9-841f-d0c9a80b2389
- Local pid:
- pubs:38936
- Source identifiers:
-
38936
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Imwong et al
- Copyright date:
- 2003
- Notes:
- © 2003 Ochong et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL (http://www.malariajournal.com/content/2/1/46).
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