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Interfering with protein-protein interactions: potential for cancer therapy.

Abstract:

Genotype-specific cancer therapy promises to engender the era of personalised medicines in which rapid identification of tumour specific gene mutations coupled to rapid methods for efficacious drug identification will be applied. Aberrant signal transduction via protein-protein interactions is generally difficult to target with small molecules. However, macromolecules (macrodrugs) can be developed that interfere with protein-protein interactions by binding with high affinity and specificity t...

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Publisher copy:
10.4161/cc.7.11.6061
Journal:
Cell cycle (Georgetown, Tex.) More from this journal
Volume:
7
Issue:
11
Pages:
1569-1574
Publication date:
2008-06-01
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
Language:
English
Keywords:
Pubs id:
pubs:324259
UUID:
uuid:a131197e-ad8e-44bc-aca2-10750030ff39
Local pid:
pubs:324259
Source identifiers:
324259
Deposit date:
2013-11-16

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