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Thesis

Sequencing of the 16S rRNA gene of the gut microbiota in mice treated with a high fibre diet as a potential endogenous mechanism of radiosensitisation

Abstract:: New non-toxic radiosensitisers are needed in the treatment of muscle-invasive bladder cancer because elderly patients are very vulnerable to chemotherapy-related toxicity of currently available radiosensitisers. Histone deacetylase (HDAC) inhibition is a promising mechanism of radiosensitisation. Tumour cells can accumulate butyrate which is produced by the gut microbiota via fibre fermentation to sufficient levels to cause HDAC inhibition, due to the Warburg effect. This has been seen whe...
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APA Style

Then, C. K. (2019). Sequencing of the 16S rRNA gene of the gut microbiota in mice treated with a high fibre diet as a potential endogenous mechanism of radiosensitisation [Master's thesis]. University of Oxford.

MLA Style

Then, C. K. Sequencing of the 16S RRNA Gene of the Gut Microbiota in Mice Treated with a High Fibre Diet as a Potential Endogenous Mechanism of Radiosensitisation. University of Oxford, 2019.

Chicago Style

Then, CK. 2019. “Sequencing of the 16S RRNA Gene of the Gut Microbiota in Mice Treated with a High Fibre Diet as a Potential Endogenous Mechanism of Radiosensitisation.” Master's thesis, University of Oxford.
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Authors

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Division:

MSD

Department:

Oncology

Role:

Author

Contributors

Role:

Supervisor

Bibliographic Details

Type of award:: MSc by Research
Level of award:: Masters
Awarding institution:: University of Oxford

Item Description

UUID:: uuid:a12a491b-17fe-4f80-8b8a-da2bbb371389
Deposit date:: 2019-09-23

Terms of use

Copyright date:: 2019

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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