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Journal article

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.

Abstract:

In each influenza season, a distinct group of young, otherwise healthy individuals with no risk factors succumbs to life-threatening infection. To better understand the cause for this, we analyzed a broad range of immune responses in blood from a unique cohort of patients, comprising previously healthy individuals hospitalized with and without respiratory failure during one influenza season, and infected with one specific influenza A strain. This analysis was compared with similarly hospitali...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1172/jci.insight.91868

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
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Higher Education Funding Council for England More from this funder
Imperial College More from this funder
Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
JCI Insight Journal website
Volume:
2
Issue:
7
Pages:
e91868
Publication date:
2017-04-05
DOI:
EISSN:
2379-3708
Pubs id:
pubs:691234
URN:
uri:a11f53d5-7fd0-4467-a6ff-3dce7f542e46
UUID:
uuid:a11f53d5-7fd0-4467-a6ff-3dce7f542e46
Local pid:
pubs:691234
Language:
English
Keywords:

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