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Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

Abstract:

It has been reported previously that the bcl-2 protooncogene protein is detectable in neoplastic cells from cases of human lymphoma in which the 14;18 chromosomal translocation is present, but not in lymphomas that lack this chromosomal rearrangement or in normal lymphoid tissue. In the present study we confirmed, by immunohistologic labeling with polyclonal and monoclonal antibodies, that bcl-2 protein is strongly expressed in many cases of follicular lymphoma and that these neoplastic folli...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Lab Sciences
Role:
Author
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Journal:
American journal of pathology
Volume:
137
Issue:
2
Pages:
225-232
Publication date:
1990-08-01
EISSN:
1525-2191
ISSN:
0002-9440
Source identifiers:
486745

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