Journal article : Review
Autophagy in major human diseases
- Abstract:
- Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.1MB, Terms of use)
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- Publisher copy:
- 10.15252/embj.2021108863
Authors
+ National Institutes of Health
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- Funder identifier:
- http://dx.doi.org/10.13039/100000002
- Publisher:
- EMBO Press
- Journal:
- EMBO Journal More from this journal
- Volume:
- 40
- Issue:
- 19
- Article number:
- e108863
- Publication date:
- 2021-08-30
- Acceptance date:
- 2021-07-12
- DOI:
- EISSN:
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1460-2075
- ISSN:
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0261-4189
- Pmid:
-
34459017
- Language:
-
English
- Keywords:
- Subtype:
-
Review
- Pubs id:
-
1193603
- Local pid:
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pubs:1193603
- Deposit date:
-
2022-01-24
- ARK identifier:
Terms of use
- Copyright holder:
- Klionsky et al.
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Authors. Published under the terms of the CC BY 4.0 license. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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