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Journal article

A large AZFc deletion removes DAZ3/DAZ4 and nearby genes from men in Y haplogroup N.

Abstract:

Deletion of the entire AZFc locus on the human Y chromosome leads to male infertility. The functional roles of the individual gene families mapped to AZFc are, however, still poorly understood, since the analysis of the region is complicated by its repeated structure. We have therefore used single-nucleotide variants (SNVs) across approximately 3 Mb of the AZFc sequence to identify 17 AZFc haplotypes and have examined them for deletion of individual AZFc gene copies. We found five individuals...

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Publication status:
Published

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Publisher copy:
10.1086/381132

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Journal:
American journal of human genetics
Volume:
74
Issue:
1
Pages:
180-187
Publication date:
2004-01-01
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
Source identifiers:
32549
Language:
English
Keywords:
Pubs id:
pubs:32549
UUID:
uuid:a1079deb-8a98-4462-9c96-c23ef01b43fd
Local pid:
pubs:32549
Deposit date:
2012-12-19

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