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Rapid detection of colicin E9-induced DNA damage using Escherichia coli cells carrying SOS promoter-lux fusions.

Abstract:

ColE9 is a plasmid-encoded protein antibiotic produced by Escherichia coli and closely related species that kills E. coli cells expressing the BtuB receptor. The 15-kDa cytotoxic DNase domain of colicin E9 preferentially nicks double-stranded DNA at thymine bases and shares a common active-site structural motif with a variety of other nucleases, including the H-N-H homing endonucleases and the apoptotic CAD proteins of eukaryotes. Studies of the mechanism by which the DNase domain of ColE9 re...

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Journal:
Journal of bacteriology
Volume:
187
Issue:
14
Pages:
4900-4907
Publication date:
2005-07-05
DOI:
EISSN:
1098-5530
ISSN:
0021-9193
URN:
uuid:a106eb61-d293-4706-bb7b-e314162cd1fb
Source identifiers:
310228
Local pid:
pubs:310228

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