Journal article
Exploratory study into the effect of abdominal mass loading on airways resistance and ventilatory failure
- Abstract:
- Objective We hypothesised that the airway resistance during tidal breathing would correlate with a particular pattern of increasing obesity, particularly when supine, and would differ between participants with and without ventilatory failure. Methods In our cross-sectional cohort study, 72 morbidly obese patients (40 males, 32 females, mean body mass index (BMI) 47.2) had measurements of both airways resistance (by impulse oscillometry (IOS)) and adiposity (by dual-energy X-ray absorptiometry (DXA)). Results All measures of airways resistance increased in the supine position: total airways resistance (R5) +37% (p<0.0005); large airways resistance (R20) +29% (p<0.0005); and small airways resistance (R5–R20) +52% (p<0.0005). BMI was correlated with seated R5, seated R5–R20, supine R5 and supine R5–R20 (r=0.33 p<0.006, r=0.32 p<0.004, r=0.30 p<0.02 and r=0.36 p<0.04, respectively). Visceral adipose tissue mass was correlated with supine R5–20 (r=0.46 p<0.05). Supine measures of total airways resistance (R5) and large airways resistance (R20) differed between those with and without ventilatory failure, as did mean weight and BMI. Conclusions Our study identifies a potentially detrimental effect of the supine posture on tidal breathing airways resistance in obese patients. This change is correlated most with visceral adipose tissue mass and the small airways. We were able to demonstrate that supine increases in airways resistance during tidal breathing, within obese patients, are different between those with and without ventilatory failure.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 676.9KB, Terms of use)
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- Publisher copy:
- 10.1136/bmjresp-2016-000138
Authors
- Publisher:
- BMJ Publishing Group
- Journal:
- BMJ Open Respiratory Research More from this journal
- Volume:
- 3
- Pages:
- e000138
- Publication date:
- 2016-06-09
- Acceptance date:
- 2016-05-13
- DOI:
- EISSN:
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2052-4439
- Pmid:
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27335651
- Language:
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English
- Keywords:
- Pubs id:
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pubs:632182
- UUID:
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uuid:a0f98b40-8b10-4da5-8fc5-832468d35669
- Local pid:
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pubs:632182
- Source identifiers:
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632182
- Deposit date:
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2018-07-24
Terms of use
- Copyright holder:
- Dattani et al
- Copyright date:
- 2016
- Notes:
- © Article author(s) (or their employer(s) unless otherwise stated in the text of the article). This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
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