Yolk sac cell atlas reveals multiorgan functions during human early development

Journal article

The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence and decline of YS hematopoietic stem and progenitor cells from hemogenic endothelium and revealed a YS-specific accelerated route to macrophage production that seeds developing organs. The multiorgan functions of the YS are superseded as intraembryonic organs develop, effecting a multifaceted relay of vital functions as pregnancy proceeds.

Authors: Goh, I; Botting, RA; Rose, A; Webb, S; Engelbert, J

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: American Association for the Advancement of Science
• Journal: Science
• Volume: 381
• Issue: 6659
• Article number: eadd7564
• Publication date: 2023-08-18
• Acceptance date: 2023-07-03
• DOI: 10.1126/science.add7564
• EISSN: 1095-9203
• ISSN: 0036-8075
• Pmid: 37590359
• Language: English
• Keywords: liver; gene expression; blood coagulation; macrophages; gene expression profiling; embryonic development; hematopoiesis; pregnancy; yolk sac; FFR; atlases as topic