Journal article
Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells
- Abstract:
-
Background: Although primarily a neurodegenerative process, there is increasing awareness of peripheral disease mechanisms in Parkinson's disease. To investigate disease processes in accessible patient cells, we studied peripheral blood mononuclear cells in recently diagnosed PD patients and rapid eye movement‐sleep behavior disorder patients who have a greatly increased risk of developing PD. We hypothesized that peripheral blood mononuclear cells may recapitulate cellula...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 785.2KB)
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- Publisher copy:
- 10.1002/mds.104
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Authors
Funding
+ National Institute for Health Research
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Funding agency for:
Simon, A
Grant:
Biomedical Research Centre, Oxford
+ Wellcome Trust
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Funding agency for:
Simon, A
Grant:
Biomedical Research Centre, Oxford
UCB Pharma
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Bibliographic Details
- Publisher:
- John Wiley & Sons, Ltd. Publisher's website
- Journal:
- Movement Disorders Journal website
- Volume:
- 33
- Issue:
- 10
- Pages:
- 1580-1590
- Publication date:
- 2018-10-07
- Acceptance date:
- 2018-05-24
- DOI:
- EISSN:
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1531-8257
- ISSN:
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0885-3185
Item Description
- Keywords:
- Pubs id:
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pubs:891794
- UUID:
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uuid:a0ef7bfa-7f30-464a-bfa7-995e40916cba
- Local pid:
- pubs:891794
- Deposit date:
- 2018-07-31
Terms of use
- Copyright holder:
- Smith et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited
- Licence:
- CC Attribution (CC BY)
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