Toll links metabolism and microbiota in the Drosophila intestine

Thesis

Peptidoglycan recognition protein SA (PGRP-SA) is an extracellular recognition protein, which interacts with the peptidoglycan of Gram-positive bacteria and activates the Toll signalling pathway. While many studies have described the interaction of PGRP-SA with pathogenic bacteria, studies on its response to commensal bacteria is lacking. Using Drosophila melanogaster as a model organism, we demonstrate the relationship between PGRP-SA with the indigenous gut microbiota, and how the activi...

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Authors: Bahuguna, S

• Alternative title: Innate immunity and metabolism together shapes the gut microbiota of Drosophila
• Type of award: MSc by Research
• Level of award: Masters
• Awarding institution: University of Oxford
• Language: English
• Keywords: Toll pathway; 4E-BP; Lactobacillaceae; Gut microbiota; Rapamycin; mTOR pathway
• Subjects: Drosophila melanogaster