Cellular confocal fluorescence studies and cytotoxic activity of new Zn(II) bis(thiosemicarbazonato) complexes.

Journal article

We report the synthesis and characterisation of new, highly fluorescent, zinc complexes of bis(thiosemicarbazone) ligands incorporating extended aromatic backbones which are cytotoxic at levels comparable to cisplatin; cellular fluorescence imaging studies suggest these cause cell death by disruption of mitochondria.

Authors: Pascu, S; Waghorn, P; Conry, T; Lin, B; Betts, H

• Publication status: Published
• Journal: Dalton transactions (Cambridge, England : 2003)
• Issue: 16
• Pages: 2107-2110
• Publication date: 2008-04-01
• DOI: 10.1039/b802806k
• EISSN: 1477-9234
• ISSN: 1477-9226
• Language: English
• Keywords: Carcinoma; Zinc; Humans; Lethal Dose 50; Drug Screening Assays, Antitumor; Apoptosis; Crystallography, X-Ray; Mitochondria; Thiosemicarbazones; Cell Line, Tumor; Spectrometry, Fluorescence; Models, Molecular; Organometallic Compounds; Toxicity Tests; Molecular Structure; Microscopy, Confocal