Journal article
A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
- Abstract:
-
Nonsense-mediated decay (NMD) eliminates transcripts with premature termination codons. Although NMD-induced loss-of-function has been shown to contribute to the genesis of particular cancers, its global functional consequence in tumours has not been characterized. Here we develop an algorithm to predict NMD and apply it on somatic mutations reported in The Cancer Genome Atlas. We identify more than 73 K mutations that are predicted to elicit NMD (NMD-elicit). NMD-elicit mutations in tumour s...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Medical Research Council
More from this funder
Funding agency for:
Yau, C
Grant:
090532/Z/09/Z
G0902418
+ China Scholarship Council
More from this funder
Funding agency for:
Hu, Z
Grant:
GAF1516_CSCUO_839316
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Communications Journal website
- Volume:
- 8
- Pages:
- 1-9
- Publication date:
- 2017-06-26
- Acceptance date:
- 2017-05-15
- DOI:
- ISSN:
-
2041-1723
- Pmid:
-
28649990
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:702313
- UUID:
-
uuid:a0cd9820-9f98-4b71-9d6c-8b3f09c62510
- Local pid:
- pubs:702313
- Source identifiers:
-
702313
- Deposit date:
- 2017-12-19
Terms of use
- Copyright holder:
- © Hu, Yau, and Ahmed 2017
- Copyright date:
- 2017
- Notes:
- This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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