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Journal article

Sex-biased genetic effects on gene regulation in humans.

Abstract:

Human regulatory variation, reported as expression quantitative trait loci (eQTLs), contributes to differences between populations and tissues. The contribution of eQTLs to differences between sexes, however, has not been investigated to date. Here we explore regulatory variation in females and males and demonstrate that 12%-15% of autosomal eQTLs function in a sex-biased manner. We show that genes possessing sex-biased eQTLs are expressed at similar levels across the sexes and highlight case...

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Publication status:
Published

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Publisher copy:
10.1101/gr.134981.111

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Journal:
Genome research
Volume:
22
Issue:
12
Pages:
2368-2375
Publication date:
2012-12-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:a0b4d04d-f7a7-43a2-9305-0ace4cd3b6c0
Source identifiers:
368112
Local pid:
pubs:368112

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