- Abstract:
-
We defined response in acute pain trials to percentage of maximum possible efficacy. Minimum efficacy criteria (MEC) of 0%, or at least 15%, 30%, 50%, and 70% pain relief were used to examine stability over time using total pain relief and summed pain intensity difference (SPID), sex differences, and sensitivity. We used individual patient data from placebo-controlled third molar extraction trials: 4 with single-dose oral etoriocoxib 120 mg, and 2 with paracetamol, ibuprofen, and ibuprofen pl...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1016/j.pain.2010.11.030
-
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- Funding agency for:
- R. Andrew Moore
- Publisher:
- Elsevier Publisher's website
- Journal:
- Pain® Journal website
- Volume:
- 152
- Issue:
- 5
- Pages:
- 982-989
- Publication date:
- 2011-05-05
- DOI:
- ISSN:
-
0304-3959
- URN:
-
uuid:a0ab5124-9ca5-4191-ae12-320e8c32af10
- Local pid:
- ora:5441
- Language:
- English
- Keywords:
- Subjects:
- Copyright holder:
- International Association for the Study of Pain
- Copyright date:
- 2010
- Notes:
- The full-text of this article is not available in ORA, but you may be able to access the article via the publisher copy link on this record page.
Journal article
Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen/paracetamol combinations after third molar extraction
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+ National Institute for Health Research Biomedical Research Centre Programme
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Oxford Pain Relief Trust
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