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Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials: examples of etoricoxib, paracetamol, ibuprofen/paracetamol combinations after third molar extraction

Abstract:

We defined response in acute pain trials to percentage of maximum possible efficacy. Minimum efficacy criteria (MEC) of 0%, or at least 15%, 30%, 50%, and 70% pain relief were used to examine stability over time using total pain relief and summed pain intensity difference (SPID), sex differences, and sensitivity. We used individual patient data from placebo-controlled third molar extraction trials: 4 with single-dose oral etoriocoxib 120 mg, and 2 with paracetamol, ibuprofen, and ibuprofen pl...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.pain.2010.11.030

Authors


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Institution:
"Pain Research", "University of Oxford"
Department:
Medical Sciences Division - Anaesthetics,Nuffield Department of
More by this author
Institution:
University Medical Center Göttingen, Göttingen, Germany
Department:
Department of Occupational and Social Medicine
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Institution:
Spreadsheet Factory, Oxford, UK
More by this author
Institution:
"Pain Research", "University of Oxford"
Department:
Medical Sciences Division - Anaesthetics,Nuffield Department of
More by this author
Institution:
"Pain Research", "University of Oxford"
Department:
Medical Sciences Division - Anaesthetics,Nuffield Department of
Oxford Pain Relief Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Pain® Journal website
Volume:
152
Issue:
5
Pages:
982-989
Publication date:
2011-05-05
DOI:
ISSN:
0304-3959
URN:
uuid:a0ab5124-9ca5-4191-ae12-320e8c32af10
Local pid:
ora:5441

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