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The pathophysiology of heart failure: a tale of two old paradigms revisited.

Abstract:

Although our current appreciation of the detrimental role of neurohumoral activation in heart failure (HF) has been intellectually appealing and has led to neurohumoral antagonism that has reduced morbidity and mortality from HF, the persisting disability and death rates remain unacceptably high. In the search for novel strategies to improve on these outcomes, we must reacquaint ourselves with basic cardiac physiology at levels ranging from the molecular to the systemic in order to identify n...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
Journal:
Clinical medicine (London, England)
Volume:
8
Issue:
2
Pages:
192-197
Publication date:
2008-04-05
DOI:
EISSN:
1473-4893
ISSN:
1470-2118
URN:
uuid:a096ec92-e73c-45d3-827a-0a1590f6d617
Source identifiers:
164530
Local pid:
pubs:164530

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