Role of matrix metalloproteinase 9 in pituitary tumor behavior.

Journal article

The matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases that are able to degrade the extracellular matrix and allow angiogenesis and tumor invasion. The vast majority of pituitary tumors are benign and do not metastasize to distant sites, although they may invade locally. The aim of this study was to determine whether expression of the collagenase MMP-9 may play a role in allowing angiogenesis and invasion by different pituitary tumor types. Tumor expression of MMP...

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Authors: Turner, H; Nagy, Z; Esiri, M; Harris, A; Wass, J

• Publication status: Published
• Journal: Journal of clinical endocrinology and metabolism
• Volume: 85
• Issue: 8
• Pages: 2931-2935
• Publication date: 2000-08-01
• DOI: 10.1210/jc.85.8.2931
• EISSN: 1945-7197
• ISSN: 0021-972X
• Language: English
• Keywords: Humans; Pituitary Gland, Anterior; Prolactinoma; Pituitary Neoplasms; Neovascularization, Pathologic; Neoplasm Recurrence, Local; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Carcinoma; Prolactin; Immunohistochemistry; Adenoma