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Vaccinia virus uses retromer-independent cellular retrograde transport pathways to facilitate the wrapping of intracellular mature virions during virus morphogenesis

Abstract:

Poxviruses, such as vaccinia virus (VACV), undertake a complex cytoplasmic replication cycle which involves morphogenesis through four distinct virion forms and includes a crucial wrapping step whereby intracellular mature virions (IMVs) are wrapped in two additional membranes to form intracellular enveloped virions (IEVs). To determine if cellular retrograde transport pathways are required for this wrapping step, we examined VACV morphogenesis in cells with reduced expression of the tetramer...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/JVI.01464-16

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; CCMP
Role:
Author
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Contributors

Role:
Editor
University of Edinburgh More from this funder
French National Research Agency More from this funder
Lermit LabEx More from this funder
Ile de France Region More from this funder
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Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
90
Issue:
22
Pages:
10120-10132
Publication date:
2018-08-31
Acceptance date:
2016-08-22
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Pubs id:
pubs:859569
URN:
uri:a07678e3-cc11-40cc-a07b-2ee0c4c00e32
UUID:
uuid:a07678e3-cc11-40cc-a07b-2ee0c4c00e32
Local pid:
pubs:859569

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