Journal article
Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model.
- Abstract:
-
Although there is growing evidence for a role of excess intracellular cations, particularly calcium ions, in neuronal and glial cell injury in multiple sclerosis, as well as in non-inflammatory neurological conditions, the molecular mechanisms involved are not fully determined. We previously showed that the acid-sensing ion channel 1 which, when activated under the acidotic tissue conditions found in inflammatory lesions opens to allow influx of sodium and calcium ions, contributes to axonal ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1093/brain/awq337
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Bibliographic Details
- Journal:
- Brain : a journal of neurology
- Volume:
- 134
- Issue:
- Pt 2
- Pages:
- 571-584
- Publication date:
- 2011-02-01
- DOI:
- EISSN:
-
1460-2156
- ISSN:
-
0006-8950
- Source identifiers:
-
241935
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:241935
- UUID:
-
uuid:a06ade60-1074-415e-90e1-cefbe27e02b4
- Local pid:
- pubs:241935
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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