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NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway

Abstract:

The effector functions of natural killer cells are regulated by activating receptors, which recognize stress-inducible ligands expressed on target cells and signal through association with signaling adaptors. Here we developed a mouse model in which a fusion of the signaling adaptor DAP10 and ubiquitin efficiently downregulated expression of the activating receptor NKG2D on the surfaces of natural killer cells. With this system, we identified coupling of the signaling pathways triggered by NK...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ni1524

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0003-1441-1727
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Name:
NIAID NIH HHS
Grant:
AI-055502
Publisher:
Springer Nature
Journal:
Nature Immunology More from this journal
Issue:
12
Publication date:
2007-10-21
Acceptance date:
2007-09-18
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Pmid:
17952078
Language:
English
Keywords:
Pubs id:
pubs:627588
UUID:
uuid:a0615f1e-c63e-4e0c-84ff-8b95cd2711aa
Local pid:
pubs:627588
Source identifiers:
627588
Deposit date:
2018-03-05

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