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Coarse-grained modelling of the structural properties of DNA origami

Abstract:

We use the oxDNA coarse-grained model to provide a detailed characterization of the fundamental structural properties of DNA origami, focussing on archetypal 2D and 3D origami. The model reproduces well the characteristic pattern of helix bending in a 2D origami, showing that it stems from the intrinsic tendency of anti-parallel four-way junctions to splay apart, a tendency that is enhanced both by less screened electrostatic interactions and by increased thermal motion. We also compare to th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/nar/gky1304

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Physics
Sub department:
Theoretical Physics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Oxford college:
Queens College
Role:
Author
ORCID:
0000-0002-2226-9524
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Name:
Engineering and Physical Sciences Research Council
Grant:
EP/I001352/1
Publisher:
Oxford University Press
Journal:
Nucleic Acids Research More from this journal
Volume:
47
Issue:
3
Pages:
1585–1597
Publication date:
2019-01-03
Acceptance date:
2018-12-20
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Keywords:
Pubs id:
pubs:921469
UUID:
uuid:a04b433b-87c2-407d-946d-9af84dd30f79
Local pid:
pubs:921469
Source identifiers:
921469
Deposit date:
2019-01-08

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