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111In-BnDTPA-F3: An Auger electron-emitting radiotherapeutic agent that targets nucleolin

Abstract:

Introduction: The F3 peptide (KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK), a fragment of the human high mobility group protein 2, binds nucleolin. Nucleolin is expressed in the nuclei of normal cells but is also expressed on the membrane of some cancer cells. The goal was to investigate the use of 111In-labeled F3 peptide for Auger electron-targeted radiotherapy. Methods: F3 was labeled with fluorescein isothiocyanate (FITC) for confocal microscopy and conjugated to p-SCNbenzyl- diethylenetriaminepentaa...

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Publisher copy:
10.1186/2191-219X-2-9

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Journal:
Dermatology and Therapy
Volume:
2
Issue:
1
Pages:
1-12
Publication date:
2012-01-01
DOI:
EISSN:
2190-9172
Source identifiers:
344636
Language:
English
Keywords:
Pubs id:
pubs:344636
UUID:
uuid:a03c4350-a753-4611-83c2-c40e17500c54
Local pid:
pubs:344636
Deposit date:
2013-11-16

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