Journal article : Review
The therapeutic potential of natural killer cells in neuropathic pain
- Abstract:
- Novel, disease-modifying treatments for neuropathic pain are urgently required. The cellular immune response to nerve injury represents a promising target for therapeutic development. Recently, the role of natural killer (NK) cells in both the central and peripheral nervous system disease has been the subject of growing interest. In this opinion piece, we set out the case for NK cell-based intervention as a promising avenue for development in the management of neuropathic pain. We explore the potential cellular and molecular targets of NK cells in the peripheral nervous system by contrasting with their reported functional roles in central nervous system diseases, and suggest strategies for utilizing the beneficial functions of NK cells and immune-based therapeutics in the context of neuropathic pain.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 848.2KB, Terms of use)
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- Publisher copy:
- 10.1016/j.tins.2023.05.008
Authors
- Publisher:
- Cell Press
- Journal:
- Trends in Neurosciences More from this journal
- Volume:
- 46
- Issue:
- 8
- Pages:
- 617-627
- Publication date:
- 2023-06-27
- Acceptance date:
- 2023-05-17
- DOI:
- EISSN:
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1878-108X
- ISSN:
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0166-2236
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1343634
- Local pid:
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pubs:1343634
- Deposit date:
-
2023-05-22
- ARK identifier:
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2023
- Rights statement:
- © 2023 Elsevier Ltd. All rights reserved.
- Notes:
- For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript (AAM) version arising from this submission. This is the accepted manuscript version of the article. The final version is available online from Cell Press at: https://doi.org/10.1016/j.tins.2023.05.008
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