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Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.

Abstract:

The mechanosensitive two-pore domain (K2P) K(+) channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use molecular dynamics simulations to examine their behavior in a lipid bilayer. We show that TREK-2 moves from the "down" to "up" conformation in direct response to membrane stretch, and examine the role of the transmembrane pressure profile in this process. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.str.2017.03.006

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Institution:
University of Oxford
Department:
Oxford, Physiology Anatomy & Genetics, OXION
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, Physiology Anatomy & Genetics, OXION
Role:
Author
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Wellcome Trust More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Deutsche Forschungsgemeinschaft More from this funder
Publisher:
Cell Press Publisher's website
Journal:
Structure Journal website
Publication date:
2017-04-06
Acceptance date:
2017-03-10
DOI:
EISSN:
1878-4186
ISSN:
0969-2126
Pubs id:
pubs:679828
URN:
uri:a02f3096-8f94-4642-89ac-0a4a4aa1675f
UUID:
uuid:a02f3096-8f94-4642-89ac-0a4a4aa1675f
Local pid:
pubs:679828

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