Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.
The mechanosensitive two-pore domain (K2P) K(+) channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use molecular dynamics simulations to examine their behavior in a lipid bilayer. We show that TREK-2 moves from the "down" to "up" conformation in direct response to membrane stretch, and examine the role of the transmembrane pressure profile in this process. ...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Copyright holder:
- Aryal et al
- Copyright date:
- © 2017 the Author(s). Published by Elsevier Ltd (Cell Press). Open Access funded by Wellcome Trust, available under a Creative Commons CC-BY 4.0 license.
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record