Journal article : Review
T cell immune memory after covid-19 and vaccination
- Abstract:
- The T cell memory response is a crucial component of adaptive immunity responsible for limiting or preventing viral reinfection. T cell memory after infection with the SARS-CoV-2 virus or vaccination is broad, and spans multiple viral proteins and epitopes, about 20 in each individual. So far the T cell memory response is long lasting and provides a high level of cross reactivity and hence resistance to viral escape by variants of the SARS-CoV-2 virus, such as the omicron variant. All current vaccine regimens tested produce robust T cell memory responses, and heterologous regimens will probably enhance protective responses through increased breadth. T cell memory could have a major role in protecting against severe covid-19 disease through rapid viral clearance and early presentation of epitopes, and the presence of cross reactive T cells might enhance this protection. T cell memory is likely to provide ongoing protection against admission to hospital and death, and the development of a pan-coronovirus vaccine might future proof against new pandemic strains.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 966.5KB, Terms of use)
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- Publisher copy:
- 10.1136/bmjmed-2022-000468
Authors
+ Wellcome Trust
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- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 222426/Z/21/Z
+ National Institute for Health and Care Research
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- Funder identifier:
- https://ror.org/0187kwz08
- Grant:
- NIHR300791
+ Medical Research Council
More from this funder
- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MR/X009297/1
- MR/X001598/1
+ UK Research and Innovation
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- Funder identifier:
- https://ror.org/001aqnf71
- Grant:
- MR/W02067X/1
- MR/W020653/1
- Publisher:
- BMJ Publishing Group
- Journal:
- BMJ Medicine More from this journal
- Volume:
- 2
- Issue:
- 1
- Article number:
- e000468
- Place of publication:
- England
- Publication date:
- 2023-11-22
- Acceptance date:
- 2023-10-23
- DOI:
- EISSN:
-
2754-0413
- Pmid:
-
38027416
- Language:
-
English
- Subtype:
-
Review
- Pubs id:
-
1573767
- Local pid:
-
pubs:1573767
- Deposit date:
-
2025-02-11
- ARK identifier:
Terms of use
- Copyright holder:
- Wang et al
- Copyright date:
- 2023
- Rights statement:
- © 2023 The Authors. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made.
- Licence:
- CC Attribution (CC BY)
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