Journal article
The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration
- Abstract:
- Dyslexia is one of the most prevalent childhood cognitive disorders, affecting ~5% of school-age children. We have identified a risk haplotype associated with dyslexia on chromosome 6p22.2 which spans the TTRAP gene and portions of THEM2 and KIAA0319. Here we show that in the presence of the risk haplotype, the expression of the KIAA0319 gene is reduced but the expression of the other two genes remains unaffected. Using in situ hybridization, we detect a very distinct expression pattern of the KIAA0319 gene in the developing cerebral neocortex of mouse and human fetuses. Moreover, interference with rat Kiaa0319 expression in utero leads to impaired neuronal migration in the developing cerebral neocortex. These data suggest a direct link between a specific genetic background and a biological mechanism leading to the development of dyslexia: the risk haplotype on chromosome 6p22.2 down-regulates the KIAA0319 gene which is required for neuronal migration during the formation of the cerebral neocortex.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, bin, 887.2KB, Terms of use)
-
(Version of record, bin, 25.0KB, Terms of use)
-
(Version of record, bin, 36.5KB, Terms of use)
-
- Publisher copy:
- 10.1093/hmg/ddl089
Authors
+ "Wellcome Trust", "Medical Research Council"
More from this funder
- Funding agency for:
- Castro, S
- Copp, A
- Publisher:
- Oxford University Press
- Journal:
- Human Molecular Genetics More from this journal
- Volume:
- 15
- Issue:
- 10
- Pages:
- 1659-1666
- Publication date:
- 2006-05-01
- Edition:
- Publisher's version
- DOI:
- EISSN:
-
1460-2083
- ISSN:
-
0964-6906
- Language:
-
English
- Keywords:
- Subjects:
- UUID:
-
uuid:9fe77835-8271-49c7-bbd0-e08485f01b99
- Local pid:
-
ora:3093
- Deposit date:
-
2009-11-25
- ARK identifier:
Terms of use
- Copyright holder:
- S Paracchini et al
- Copyright date:
- 2006
- Notes:
- Citation: Paracchini, S. et al. (2006). 'The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration', Human Molecular Genetics, 15(10), 1659-1666. [Available at http://hmg.oxfordjournals.org]. The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact: [email protected]
If you are the owner of this record, you can report an update to it here: Report update to this record