The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration

Paracchini, S; Thomas, A; Castro, S; Lai, C; Paramasivam, M; Wang, Y; Keating, B; Taylor, J; Hacking, D; Scerri, T; Francks, C; Richardson, A; Wade-Martins, R; Stein, J; Knight, J; Copp, A; LoTurco, J; Monaco, A

Journal article

The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration

Abstract:: Dyslexia is one of the most prevalent childhood cognitive disorders, affecting ~5% of school-age children. We have identified a risk haplotype associated with dyslexia on chromosome 6p22.2 which spans the TTRAP gene and portions of THEM2 and KIAA0319. Here we show that in the presence of the risk haplotype, the expression of the KIAA0319 gene is reduced but the expression of the other two genes remains unaffected. Using in situ hybridization, we detect a very distinct expression pattern of th...
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Peer review status:: Peer reviewed

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APA Style

Paracchini, S., Thomas, A., Castro, S., Lai, C., Paramasivam, M., Wang, Y., Keating, B., Taylor, J., Hacking, D., Scerri, T., Francks, C., Richardson, A., Wade-Martins, R., Stein, J., Knight, J., Copp, A., LoTurco, J., & Monaco, A. (2006). The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration. Human Molecular Genetics, 15(10), 1659–1666.

MLA Style

Paracchini, S., et al. “The Chromosome 6p22 Haplotype Associated with Dyslexia Reduces the Expression of KIAA0319, a Novel Gene Involved in Neuronal Migration.” Human Molecular Genetics, Publisher's version, vol. 15, no. 10, Oxford University Press, 2006, pp. 1659–66.

Chicago Style

Paracchini, S, A Thomas, S Castro, C Lai, M Paramasivam, Y Wang, B Keating, et al. 2006. “The Chromosome 6p22 Haplotype Associated with Dyslexia Reduces the Expression of KIAA0319, a Novel Gene Involved in Neuronal Migration.” Human Molecular Genetics 15 (10): 1659–66.
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Publisher copy:: 10.1093/hmg/ddl089

Authors

+ Paracchini, S More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Role:

Author

+ Thomas, A More by this author

Institution:

"University of Connecticut, Storrs, USA"

Department:

Department of Physiology and Neurobiology

Role:

Author

+ Castro, S More by this author

Institution:

"University College London"

Department:

Neural Development Unit,Institute of Child Health

Role:

Author

+ Lai, C More by this author

Institution:

"University College London"

Department:

Wolfson Institute for Biomedical Research

Role:

Author

+ Paramasivam, M More by this author

Institution:

"University of Connecticut, Storrs, USA"

Department:

Department of Physiology and Neurobiology

Role:

Author

More authors...

Funding

+ NIH More from this funder

Funding agency for:

Paramasivam, M

Wang, Y

LoTurco, J

+ "Wellcome Trust", "Medical Research Council" More from this funder

Funding agency for:

Castro, S

Copp, A

+ Wellcome Trust More from this funder

Funding agency for:

Monaco, A

Bibliographic Details

Publisher:: Oxford University Press
Journal:: Human Molecular Genetics More from this journal
Volume:: 15
Issue:: 10
Pages:: 1659-1666
Publication date:: 2006-05-01
DOI:: 10.1093/hmg/ddl089
EISSN:: 1460-2083
ISSN:: 0964-6906

Item Description

Language:: English
Keywords:: dyslexia
Subjects:: Neuroscience

Neurogenetics

Genetics (medical sciences)
UUID:: uuid:9fe77835-8271-49c7-bbd0-e08485f01b99
Local pid:: ora:3093
Deposit date:: 2009-11-25

Terms of use

Copyright holder:: S Paracchini et al
Notes:: Citation: Paracchini, S. et al. (2006). 'The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration', Human Molecular Genetics, 15(10), 1659-1666. [Available at http://hmg.oxfordjournals.org]. The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact: journals.permissions@oxfordjournals.org

Licence:: CC Attribution-NonCommercial (CC BY-NC)

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Journal article

The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration

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