Are statins useful in patients with advanced chronic kidney disease? - authors' reply

Journal article : Letter

In our meta-analysis of individual participant data from 28 trials of statin-based therapy there was a significant trend towards smaller relative risk reductions for the composite outcome of major vascular events (myocardial infarction or death from coronary heart disease, stroke or coronary revascularisation) with declining estimated glomerular filtration rate (eGFR).1 Whilst a trend was present for major coronary events, neither of the corresponding trends for coronary revascularisation procedures and stroke were statistically significant. Since the number of coronary revascularisations and stroke were relatively small among those with advanced chronic kidney disease (CKD), however, it is not possible to determine reliably whether the trends in relative risk reductions differ for specific vascular events.

Authors: Herrington, W; Emberson, J; Mihaylova, B; Collins, R; Baigent, C

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Lancet Diabetes and Endocrinology
• Volume: 4
• Issue: 12
• Pages: 971-972
• Publication date: 2016-11-23
• Acceptance date: 2016-10-12
• DOI: 10.1016/S2213-8587(16)30266-2
• EISSN: 2213-8595
• ISSN: 2213-8587
• Language: English
• Subtype: Letter