Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.

Journal article

Although several cancer immunotherapy strategies are based on the use of analog peptides and on the modulation of the TCR affinity of adoptively transferred T cells, it remains unclear whether tumor-specific T cell activation by strong and weak TCR stimuli evoke different Ca(2+) signatures from the Ca(2+) intracellular stores and whether the amplitude of Ca(2+) release from the endoplasmic reticulum (ER) can be further modulated by coreceptor binding to peptide/MHC. In this study, we combined...

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Authors: Chen, J; Morgan, A; Stewart-Jones, G; Shepherd, D; Bossi, G

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 184
• Issue: 4
• Pages: 1829-1839
• Publication date: 2010-02-01
• DOI: 10.4049/jimmunol.0902103
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Protein Isoforms; Endoplasmic Reticulum; Protein Binding; Peptide Fragments; Crystallography, X-Ray; Epitopes, T-Lymphocyte; Humans; Cytoplasmic Granules; Clone Cells; Receptors, Antigen, T-Cell; Neoplasm Proteins; T-Lymphocyte Subsets; Lymphocyte Activation; Calcium; Cytotoxicity Tests, Immunologic