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Journal article

Isolation of ORCTL3 in a novel genetic screen for tumor-specific apoptosis inducers.

Abstract:

We have established a systematic high-throughput screen for genes that cause cell death specifically in transformed tumor cells. In a first round of screening, cDNAs that induce apoptosis in a transformed human cell line are detected. Positive genes are subsequently tested in a synthetic lethal screen in normal cells versus their isogenic counterparts that have been transformed by a particular oncogene. In this way, the organic cation transporter-like 3 (ORCTL3) gene was found to be inactive ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/cdd.2009.21

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
Role:
Author
Cancer Research UK More from this funder
Breast Cancer Campaign More from this funder
European Union More from this funder
Publisher:
Nature Publisher's website
Journal:
Cell death and differentiation Journal website
Volume:
16
Issue:
6
Pages:
890-898
Publication date:
2009-06-05
DOI:
EISSN:
1476-5403
ISSN:
1350-9047
URN:
uuid:9fa4558d-64cb-401d-9bba-f0167bf4d20e
Source identifiers:
548553
Local pid:
pubs:548553

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