Journal article

Subcellular organisation of the cAMP signalling pathway

Abstract:: The field of cAMP signaling is witnessing exciting developments with the recognition that cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal coding. This realization has changed our understanding of cAMP signaling from a model in which cAMP connects a receptor at the plasma membrane to an intracellular effector in a linear pathway to a model in which cAMP signals propagate within a complex network of alternative branches and the specific functional outcome strictly depends on local regulation of cAMP levels and on selective activation of a limited number of branches within the network. In this review, we cover some of the early studies and summarize more recent evidence supporting the model of compartmentalized cAMP signaling, and we discuss how this knowledge is starting to provide original mechanistic insight into cell physiology and a novel framework for the identification of disease mechanisms that potentially opens new avenues for therapeutic interventions.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Zaccolo, M., Zerio, A., & Lobo, M. J. (2020). Subcellular organisation of the cAMP signalling pathway. Pharmacological Reviews, 73(1), 278–309.

MLA Style

Zaccolo, M, et al. “Subcellular Organisation of the CAMP Signalling Pathway.” Pharmacological Reviews, vol. 73, no. 1, 2020, pp. 278–309.

Chicago Style

Zaccolo, M, A Zerio, and MJ Lobo. 2020. “Subcellular Organisation of the CAMP Signalling Pathway.” Pharmacological Reviews 73 (1): 278–309.
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Files:: Zaccolo_et_al_Subcellular_organization.pdf

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Publisher copy:: 10.1124/pharmrev.120.000086

Authors

+ Zaccolo, M More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Physiology Anatomy & Genetics
Role:: Author

+ Zerio, A More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Physiology Anatomy & Genetics
Role:: Author

+ Lobo, MJ More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Physiology Anatomy & Genetics
Role:: Author

+ British Heart Foundation More from this funder

Grant:: RG/12/3/29423

Publisher:: American Society for Pharmacology and Experimental Therapeutics
Journal:: Pharmacological Reviews More from this journal
Volume:: 73
Issue:: 1
Pages:: 278-309
Publication date:: 2020-12-17
Acceptance date:: 2020-09-09
DOI:: 10.1124/pharmrev.120.000086
EISSN:: 1521-0081
ISSN:: 0031-6997

Language:: English
Keywords:: FFR
Pubs id:: 1133434
Local pid:: pubs:1133434
Deposit date:: 2020-09-24
ARK identifier:: ark:/29072/ora_9f9bd83aa25c4478badb42bfadfe9c91

Terms of use

Copyright holder:: Zaccolo et al.
Copyright date:: 2020
Rights statement:: Copyright © 2020 by The Author(s). This is an open access article distributed under the CC BY Attribution 4.0 International license.

Licence:: CC Attribution (CC BY)

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